134531-42-3
134531-42-3 structure
- Name: OBAA
- Chemical Name: 2-(3-octadecylbenzoyl)prop-2-enoic acid
- CAS Number: 134531-42-3
- Molecular Formula: C28H44O3
- Molecular Weight: 428.64700
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-12-05 11:23:35
- Modify Date: 2024-01-12 14:38:33
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OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM[1][2][3].
| Name | 2-(3-octadecylbenzoyl)prop-2-enoic acid |
|---|---|
| Synonyms |
OBAA
4-(4-octadecylphenyl)-4-oxo-2-Butenoic acid 3-(4-octadecyl)benzoylacrylic acid |
| Description | OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
PLA2:70 nM (IC50) |
| In Vitro | OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells had disintegrated into apoptotic bodies[1]. |
| In Vivo | The immunologically induced bronchospasm in guinea pigs is significantly and dose-dependently inhibited by OBAA (2.5-7 mg/kg i.v.)[3]. |
| References |
| Density | 0.974 g/cm3 |
|---|---|
| Boiling Point | 550.8ºC at 760 mmHg |
| Molecular Formula | C28H44O3 |
| Molecular Weight | 428.64700 |
| Flash Point | 301ºC |
| Exact Mass | 428.32900 |
| PSA | 54.37000 |
| LogP | 8.31410 |
| RIDADR | NONH for all modes of transport |
|---|