OBAA

Names

[ Name ]:
OBAA

[Synonym ]:
OBAA
4-(4-octadecylphenyl)-4-oxo-2-Butenoic acid 3-(4-octadecyl)benzoylacrylic acid

Biological Activity

[Description]:

OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Inflammation/Immunology

[Target]

PLA2:70 nM (IC50)

[In Vitro]

OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells had disintegrated into apoptotic bodies[1].

[In Vivo]

The immunologically induced bronchospasm in guinea pigs is significantly and dose-dependently inhibited by OBAA (2.5-7 mg/kg i.v.)[3].

[References]

[1]. J Y Miao, et al. Inhibitors of phospholipase promote apoptosis of human endothelial cells. J Biochem. 1997 Mar;121(3):612-8.

[2]. J Eintracht, et al. Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid. Biochem J. 1998 Dec 15;336 ( Pt 3)(Pt 3):659-66.

[3]. T Köhler, et al. Phospholipase A2 inhibition by alkylbenzoylacrylic acids. Biochem Pharmacol. 1992 Aug 18;44(4):805-13.

Chemical & Physical Properties

[ Density]:
0.974 g/cm3

[ Boiling Point ]:
550.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₈H₄₄O₃

[ Molecular Weight ]:
428.64700

[ Flash Point ]:
301ºC

[ Exact Mass ]:
428.32900

[ PSA ]:
54.37000

[ LogP ]:
8.31410

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Bile acid modulates transepithelial permeability via the generation of reactive oxygen species in the Caco-2 cell line.

Free Radic. Biol. Med. 39(6) , 769-80, (2005)

The barrier functions in epithelial and endothelial cells seem to be very important for maintaining normal biological homeostasis. However, it is unclear whether or how bile acids affect the epithelia...

Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid.

Biochem. J. 336 ( Pt 3) , 659-66, (1998)

In contrast with mammalian cells, little is known about the control of Ca2+ entry into primitive protozoans. Here we report that Ca2+ influx in pathogenic Trypanosoma brucei can be regulated by phosph...