221632-26-4

221632-26-4 structure

Name: OBAA
Chemical Name: 4-(4-Octadecylphenyl)-4-oxo-2-butenoic acid
CAS Number: 221632-26-4
Molecular Formula: C₂₈H₄₄O₃
Molecular Weight: 428.647
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-07-11 04:53:40
Modify Date: 2024-01-13 10:10:23
(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM[1][2][3][4].

Name	4-(4-Octadecylphenyl)-4-oxo-2-butenoic acid
Synonyms	(2E)-4-(4-Octadecylphenyl)-4-oxo-2-butenoic acid 2-Butenoic acid, 4-(4-octadecylphenyl)-4-oxo-, (2E)- (2E)-4-(4-Octadecylphenyl)-4-oxobut-2-enoic acid 4-(4-Octadecylphenyl)-4-oxo-2-butenoic acid

Description	(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Inflammation/Immunology
Target	PLA2:70 nM (IC50)
In Vitro	(2E)-OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells has disintegrated into apoptotic bodies[1].
In Vivo	(2E)-OBAA (2.5-7 mg/kg, IV) significantly and dose-dependently inhibits the immunologically induced bronchospasm in guinea pigs[3].
References	[1]. J Y Miao, et al. Inhibitors of phospholipase promote apoptosis of human endothelial cells. J Biochem. 1997 Mar;121(3):612-8. [2]. J Eintracht, et al. Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid. Biochem J. 1998 Dec 15;336 ( Pt 3)(Pt 3):659-66. [3]. T Köhler, et al. Phospholipase A2 inhibition by alkylbenzoylacrylic acids. Biochem Pharmacol. 1992 Aug 18;44(4):805-13. [4]. Kethineedi VR, et al. Quantum dot-NBD-liposome luminescent probes for monitoring phospholipase A2 activity. Anal Bioanal Chem. 2013 Dec;405(30):9729-37.