Dehydroandrographolide

Modify Date: 2024-01-02 15:21:22

Dehydroandrographolide structure	Common Name	Dehydroandrographolide
	CAS Number	134418-28-3	Molecular Weight	332.43
	Density	1.2±0.1 g/cm3	Boiling Point	512.8±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₈O₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	178.3±23.6 °C

Use of Dehydroandrographolide

Dehydroandrographolide is extracted from herbal medicine Andrographis paniculata (Burm f) Nees; alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.

Name	Dehydroandrographolide
Synonym	More Synonyms

Description	Dehydroandrographolide is extracted from herbal medicine Andrographis paniculata (Burm f) Nees; alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Natural Products >> Terpenoids and Glycosides Research Areas >> Infection
References	[1]. Chen Q, et al. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenous administration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012 Oct;33(10):1332-6. [2]. Chao WW, et al. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med. 2010 May 13;5:17. [3]. Basak A, et al. Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Biochem J. 1999 Feb 15;338 ( Pt 1):107-13. [4]. Zhu T, et al. Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1238-41. [5]. Chen H, et al. Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents. Bioorg Med Chem Lett. 2014 May 15;24(10):2353-9.

Description

Dehydroandrographolide is extracted from herbal medicine Andrographis paniculata (Burm f) Nees; alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.

Related Catalog

Signaling Pathways >> Anti-infection >> Influenza Virus

Natural Products >> Terpenoids and Glycosides

Research Areas >> Infection

References

[1]. Chen Q, et al. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenous administration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012 Oct;33(10):1332-6.

[2]. Chao WW, et al. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med. 2010 May 13;5:17.

[3]. Basak A, et al. Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Biochem J. 1999 Feb 15;338 ( Pt 1):107-13.

[4]. Zhu T, et al. Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1238-41.

[5]. Chen H, et al. Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents. Bioorg Med Chem Lett. 2014 May 15;24(10):2353-9.

Density	1.2±0.1 g/cm3
Boiling Point	512.8±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₈O₄
Molecular Weight	332.43
Flash Point	178.3±23.6 °C
PSA	86.99000
LogP	2.97
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.584

Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
RTECS	LU3490300

(3E)-4-Hydroxy-3-{2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl]ethylidene}furan-2(3H)-one

Dehydroanddrographolide

2(3H)-Furanone,3-[2-[(1S,4aS,5R,6R,8aS)-decahydro

DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

(3E)-4-Hydroxy-3-{2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}-2(3H)-furanone

Dehydroandrographoline

6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-,(3E)

ANDROGRAPHOLIDE,DEHYDRO

2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-4-hydroxy-, (3E)-

14-Deoxy-11-dehydroandrographolide

Dehydrographkide

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Dehydroandrographolide
Price: ￥148.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Dehydroandrographolide
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Dehydroandrographoline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Dehydroandrographolide
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Price: $78/10mg

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Dehydroandrographolide

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