Nifurpirinol
Nifurpirinol structure
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Common Name | Nifurpirinol | ||
|---|---|---|---|---|
| CAS Number | 13411-16-0 | Molecular Weight | 246.21900 | |
| Density | 1.412 g/cm3 | Boiling Point | 416.3ºC at 760 mmHg | |
| Molecular Formula | C12H10N2O4 | Melting Point | 170-171° | |
| MSDS | Chinese USA | Flash Point | 205.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of NifurpirinolNifurpirinol (P-7138) is a nitroaromatic antibiotic and acts as a novel substrate for the bacterial nitroreductase (NTR) enzyme. Nifurpirinol is a more potent prodrug compared to Metronidazole to trigger cell-ablation in nitroreductase expressing transgenic models[1]. |
| Name | [6-[(E)-2-(5-nitrofuran-2-yl)ethenyl]pyridin-2-yl]methanol |
|---|---|
| Synonym | More Synonyms |
| Description | Nifurpirinol (P-7138) is a nitroaromatic antibiotic and acts as a novel substrate for the bacterial nitroreductase (NTR) enzyme. Nifurpirinol is a more potent prodrug compared to Metronidazole to trigger cell-ablation in nitroreductase expressing transgenic models[1]. |
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| Related Catalog | |
| Target |
IC50: bacterial nitroreductase (NTR) enzyme[1] |
| References |
| Density | 1.412 g/cm3 |
|---|---|
| Boiling Point | 416.3ºC at 760 mmHg |
| Melting Point | 170-171° |
| Molecular Formula | C12H10N2O4 |
| Molecular Weight | 246.21900 |
| Flash Point | 205.6ºC |
| Exact Mass | 246.06400 |
| PSA | 92.08000 |
| LogP | 2.76870 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.695 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Correlation of epizootiological observations with experimental data: chemical induction of chromatophoromas in the croaker, Nibea mitsukurii.
Natl. Cancer Inst. Monogr. 65 , 139-54, (1984) Chromatophoromas in the croaker nibe, Nibea mitsukurii, are common neoplasms in feral fish which inhabit the shallow water in a unique geographic distribution along the Pacific coast of Japan. We unde... |
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[Disease of the fins of Rhamdia sapo. Isolation of the etiological agents and experimental infection].
Rev. Argent. Microbiol. 20(1) , 37-48, (1988) During intensive culture of South-American catfish, Rhamdia sapo fingerlings an epizootic similar to fin rot was developed. Aeromonas hydrophila and Pseudomonas aeruginosa were isolated and they were ... |
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Mutagenicity of nifurpirinol (P-7138) in Escherichia coli WP2 and Salmonella typhimurium TA100.
Mutat. Res. 104(1-3) , 61-6, (1982) Nifurpirinol, 6-hydroxymethyl-2-[2-(5-nitro-2-furyl)vinyl]pyridine, which has been widely used as an antibacterial drug against diseases of fish, was found to be a potent mutagen. The mutagenic effect... |
| Furanace |
| Furpirinol |
| Furpirinol Furpyrinol {6-[2-(5-Nitro-2-furanyl)vinyl]-2-pyridinyl}methanol |
| Furpyrinol |
| Nifurpirinol |
| Furanace-10 |