Nifurpirinol
Names
[ CAS No. ]:
13411-16-0
[ Name ]:
Nifurpirinol
[Synonym ]:
Furanace
Furpirinol
Furpirinol Furpyrinol {6-[2-(5-Nitro-2-furanyl)vinyl]-2-pyridinyl}methanol
Furpyrinol
Nifurpirinol
Furanace-10
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: bacterial nitroreductase (NTR) enzyme[1]
[References]
Chemical & Physical Properties
[ Density]:
1.412 g/cm3
[ Boiling Point ]:
416.3ºC at 760 mmHg
[ Melting Point ]:
170-171°
[ Molecular Formula ]:
C12H10N2O4
[ Molecular Weight ]:
246.21900
[ Flash Point ]:
205.6ºC
[ Exact Mass ]:
246.06400
[ PSA ]:
92.08000
[ LogP ]:
2.76870
[ Vapour Pressure ]:
0mmHg at 25°C
[ Index of Refraction ]:
1.695
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UT5023000
- CHEMICAL NAME :
- 2-Pyridinemethanol, 6-(2-(5-nitro-2-furyl)vinyl)-
- CAS REGISTRY NUMBER :
- 13411-16-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C12-H10-N2-O4
- MOLECULAR WEIGHT :
- 246.24
- WISWESSER LINE NOTATION :
- T6NJ B1Q F1U1- BT5OJ ENW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921- Volume(issue)/page/year: 48,291,1973
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H319
[ Precautionary Statements ]:
P305 + P351 + P338
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
36
[ Safety Phrases ]:
26
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
UT5023000
[ HS Code ]:
2934999090
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Natl. Cancer Inst. Monogr. 65 , 139-54, (1984)
Chromatophoromas in the croaker nibe, Nibea mitsukurii, are common neoplasms in feral fish which inhabit the shallow water in a unique geographic distribution along the Pacific coast of Japan. We unde...
[Disease of the fins of Rhamdia sapo. Isolation of the etiological agents and experimental infection].Rev. Argent. Microbiol. 20(1) , 37-48, (1988)
During intensive culture of South-American catfish, Rhamdia sapo fingerlings an epizootic similar to fin rot was developed. Aeromonas hydrophila and Pseudomonas aeruginosa were isolated and they were ...
Mutagenicity of nifurpirinol (P-7138) in Escherichia coli WP2 and Salmonella typhimurium TA100.Mutat. Res. 104(1-3) , 61-6, (1982)
Nifurpirinol, 6-hydroxymethyl-2-[2-(5-nitro-2-furyl)vinyl]pyridine, which has been widely used as an antibacterial drug against diseases of fish, was found to be a potent mutagen. The mutagenic effect...