Nicotinamide Riboside
Modify Date: 2024-01-03 15:58:41
Nicotinamide Riboside structure
|
Common Name | Nicotinamide Riboside | ||
|---|---|---|---|---|
| CAS Number | 1341-23-7 | Molecular Weight | 255.247 | |
| Density | 1.201g/cm3 | Boiling Point | 353.7ºC at 760mmHg | |
| Molecular Formula | C11H15N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 181.9ºC | |
Use of Nicotinamide RibosideNicotinamide riboside is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside is used in dietary supplements[1]. |
| Name | N-ribosylnicotinamide |
|---|---|
| Synonym | More Synonyms |
| Description | Nicotinamide riboside is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside is used in dietary supplements[1]. |
|---|---|
| Related Catalog | |
| Target |
SIRT1 SIRT3 |
| In Vitro | Nicotinamide riboside (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.5 nM Incubation Time: 24 hours Result: Reduced the acetylation status of Ndufa9 and SOD2. |
| In Vivo | Chronic Nicotinamide riboside (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD[+] content in a tissue-specific manner[1]. Animal Model: 10-week-old C57Bl/6J mice[1] Dosage: 400 mg/kg Administration: p.o.; daily; for 16 weeks Result: Increased plasma and intracellular NAD[+] content in a tissue-specific manner. |
| References |
| Density | 1.201g/cm3 |
|---|---|
| Boiling Point | 353.7ºC at 760mmHg |
| Molecular Formula | C11H15N2O5 |
| Molecular Weight | 255.247 |
| Flash Point | 181.9ºC |
| Exact Mass | 255.097549 |
| PSA | 116.25000 |
| LogP | -2.30 |
| Vapour Pressure | 3.05E-07mmHg at 25°C |
| Index of Refraction | 1.549 |
| Hazard Codes | Xn |
|---|
|
~%
Nicotinamide Ri... CAS#:1341-23-7 |
| Literature: Angewandte Chemie - International Edition, , vol. 43, # 35 p. 4637 - 4640 |
| Precursor 2 | |
|---|---|
| DownStream 1 | |
| Pyridinium, 3-(aminocarbonyl)-1-β-D-ribofuranosyl- |
| Nicotinamide riboside-oxidized form |
| 3-Carbamoyl-1-(β-D-ribofuranosyl)pyridinium |
| Nicotinamide Ribose |
| 3-(Aminocarbonyl)-1beta-D-ribofuranosylpyridinium |
| 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridine-5-carboxamide |
| NRH-oxidized form |
| 3-(aminocarbonyl)-1-β-D-ribofuranosyl-Pyridinium |
| Nicotinamide riboside |
| N-ribosylnicotinamid |
- DC Chemicals Limited
- China
- Product Name: Nicotinamide riboside
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 3-CARBAMOYL-1-((2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)PYRIDIN-1-IUM
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: NICOTINAMIDE RIBOSIDE
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: N-ribosylnicotinamide
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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