10-formylfolic acid (25 mg)

Modify Date: 2024-01-09 07:18:04

10-formylfolic acid (25 mg) Structure
10-formylfolic acid (25 mg) structure
Common Name 10-formylfolic acid (25 mg)
CAS Number 134-05-4 Molecular Weight 469.40800
Density 1.67g/cm3 Boiling Point N/A
Molecular Formula C20H19N7O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 10-formylfolic acid (25 mg)


10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].

 Names

Name (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
Synonym More Synonyms

 10-formylfolic acid (25 mg) Biological Activity

Description 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].
Related Catalog
References

[1]. M D'Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2736-9.  

[2]. J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129(7):1315-8.  

 Chemical & Physical Properties

Density 1.67g/cm3
Molecular Formula C20H19N7O7
Molecular Weight 469.40800
Exact Mass 469.13500
PSA 221.56000
LogP 1.11410
Index of Refraction 1.748

 Safety Information

RIDADR NONH for all modes of transport

 Articles5

More Articles
Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays.

J. Agric. Food Chem. 50(17) , 4760-8, (2002)

[2H4]Folic acid was synthesized by deuterating p-aminobenzoic acid, which was then coupled to glutamic acid and 6-formylpterin. Using [2H4]folic acid as starting component enabled the preparation of l...

Folate metabolism in man: the effect of malignant disease.

Br. J. Cancer 46(3) , 346-53, (1982)

The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding inclu...

Applicability of alkyl-bonded ultra-pure silica stationary phases for gradient reversed-phase HPLC of folates with conventional and volatile buffers under highly aqueous conditions.

J. Sep. Sci. 29(6) , 889-904, (2006)

Applicability of several alkyl-bonded silica stationary phases was tested for gradient RP-HPLC of folates under highly aqueous conditions. High retention of folates was achieved on alternative phases ...

 Synonyms

10-Formylpteroylglutamic Acid
10-Formylfolic acid
N10-Formylfolic Acid