10-甲酰叶酸

更新时间：2025-08-25 11:38:17

10-甲酰叶酸结构式	常用名	10-甲酰叶酸	英文名	10-formylfolic acid (25 mg)
	CAS号	134-05-4	分子量	469.40800
	密度	1.67g/cm3	沸点	N/A
	分子式	C₂₀H₁₉N₇O₇	熔点	N/A
	MSDS	N/A	闪点	N/A

10-甲酰叶酸用途

10-Formylfolic acid 是二氢叶酸还原酶 (dihydrofolate reductase) 的有效抑制剂。10-Formylfolic acid 可用作白血病的早期指标。

中文名	10-甲酰叶酸
英文名	(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
英文别名	更多

描述	10-Formylfolic acid 是二氢叶酸还原酶 (dihydrofolate reductase) 的有效抑制剂。10-Formylfolic acid 可用作白血病的早期指标。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> 叶酸
参考文献	[1]. M D'Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2736-9. [2]. J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129(7):1315-8.

描述

10-Formylfolic acid 是二氢叶酸还原酶 (dihydrofolate reductase) 的有效抑制剂。10-Formylfolic acid 可用作白血病的早期指标。

相关类别

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 叶酸

参考文献

[1]. M D'Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2736-9.

[2]. J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129(7):1315-8.

密度	1.67g/cm3
分子式	C₂₀H₁₉N₇O₇
分子量	469.40800
精确质量	469.13500
PSA	221.56000
LogP	1.11410
折射率	1.748

危险品运输编码	NONH for all modes of transport

Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays.

J. Agric. Food Chem. 50(17) , 4760-8, (2002)

[2H4]Folic acid was synthesized by deuterating p-aminobenzoic acid, which was then coupled to glutamic acid and 6-formylpterin. Using [2H4]folic acid as starting component enabled the preparation of l...

Folate metabolism in man: the effect of malignant disease.

Br. J. Cancer 46(3) , 346-53, (1982)

The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding inclu...

Applicability of alkyl-bonded ultra-pure silica stationary phases for gradient reversed-phase HPLC of folates with conventional and volatile buffers under highly aqueous conditions.

J. Sep. Sci. 29(6) , 889-904, (2006)

Applicability of several alkyl-bonded silica stationary phases was tested for gradient RP-HPLC of folates under highly aqueous conditions. High retention of folates was achieved on alternative phases ...

10-Formylpteroylglutamic Acid

10-Formylfolic acid

N10-Formylfolic Acid