4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate

Modify Date: 2025-08-26 23:46:27

4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate structure	Common Name	4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate
	CAS Number	1338575-41-9	Molecular Weight	436.502
	Density	1.2±0.1 g/cm3	Boiling Point	655.2±55.0 °C at 760 mmHg
	Molecular Formula	C₂₈H₂₄N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	350.1±31.5 °C

Use of 4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate

WWL123 is a potent and selective ABHD6 inhibitor with an IC50 of 430 nM[1][2]. WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole (PTZ)-induced epileptiform seizures and spontaneous seizures in R6/2 mice[3].

Name	4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate
Synonym	More Synonyms

Description	WWL123 is a potent and selective ABHD6 inhibitor with an IC50 of 430 nM[1][2]. WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole (PTZ)-induced epileptiform seizures and spontaneous seizures in R6/2 mice[3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL Research Areas >> Neurological Disease
References	[1]. Daniel A Bachovchin, et al. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20941-6. [2]. Peng Zhong, et al. Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. J Physiol. 2011 Oct 15;589(Pt 20):4847-55. [3]. Alipi V Naydenov, et al. ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron. 2014 Jul 16;83(2):361-371.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL

Research Areas >> Neurological Disease

References

[1]. Daniel A Bachovchin, et al. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20941-6.

[2]. Peng Zhong, et al. Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. J Physiol. 2011 Oct 15;589(Pt 20):4847-55.

[3]. Alipi V Naydenov, et al. ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron. 2014 Jul 16;83(2):361-371.

Density	1.2±0.1 g/cm3
Boiling Point	655.2±55.0 °C at 760 mmHg
Molecular Formula	C₂₈H₂₄N₂O₃
Molecular Weight	436.502
Flash Point	350.1±31.5 °C
Exact Mass	436.178680
LogP	5.20
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.631

4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate

Carbamic acid, N-([1,1'-biphenyl]-3-ylmethyl)-N-methyl-, 4'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester

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4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate

Use of 4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate

Names

Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.