1338575-41-9

1338575-41-9 structure

Name: 4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate
Chemical Name: 4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate
CAS Number: 1338575-41-9
Molecular Formula: C₂₈H₂₄N₂O₃
Molecular Weight: 436.502
Catalog: Signaling Pathways Metabolic Enzyme/Protease MAGL
Create Date: 2018-06-22 21:36:05
Modify Date: 2025-08-26 23:46:27
WWL123 is a potent and selective ABHD6 inhibitor with an IC50 of 430 nM[1][2]. WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole (PTZ)-induced epileptiform seizures and spontaneous seizures in R6/2 mice[3].

Name	4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate
Synonyms	4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate Carbamic acid, N-([1,1'-biphenyl]-3-ylmethyl)-N-methyl-, 4'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester

Description	WWL123 is a potent and selective ABHD6 inhibitor with an IC50 of 430 nM[1][2]. WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole (PTZ)-induced epileptiform seizures and spontaneous seizures in R6/2 mice[3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL Research Areas >> Neurological Disease
References	[1]. Daniel A Bachovchin, et al. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20941-6. [2]. Peng Zhong, et al. Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. J Physiol. 2011 Oct 15;589(Pt 20):4847-55. [3]. Alipi V Naydenov, et al. ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron. 2014 Jul 16;83(2):361-371.