4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate

• 常用名: 4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate
• 英文名: 4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate
• CAS号: 1338575-41-9
• 分子量: 436.502
• 密度: 1.2±0.1 g/cm3
• 沸点: 655.2±55.0 °C at 760 mmHg
• 分子式: C₂₈H₂₄N₂O₃
• 熔点: N/A
• 闪点: 350.1±31.5 °C

用途

WWL123是一种有效的选择性ABHD6抑制剂,IC50为430nm[1][2]。WWL123穿过血脑屏障并抑制脑实质中的ABHD6。WWL123阻断ABHD6对戊四氮(PTZ)诱导的R6/2小鼠癫痫样发作和自发发作具有抗癫痫作用[3]。

名称

• 英文名: 4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate

生物活性

• 描述: WWL123是一种有效的选择性ABHD6抑制剂,IC50为430nm[1][2]。WWL123穿过血脑屏障并抑制脑实质中的ABHD6。WWL123阻断ABHD6对戊四氮(PTZ)诱导的R6/2小鼠癫痫样发作和自发发作具有抗癫痫作用[3]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> MAGL
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Daniel A Bachovchin, et al. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20941-6.

  [2]. Peng Zhong, et al. Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. J Physiol. 2011 Oct 15;589(Pt 20):4847-55.

  [3]. Alipi V Naydenov, et al. ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron. 2014 Jul 16;83(2):361-371.

物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 655.2±55.0 °C at 760 mmHg
• 分子式: C₂₈H₂₄N₂O₃
• 分子量: 436.502
• 闪点: 350.1±31.5 °C
• 精确质量: 436.178680
• LogP: 5.20
• InChIKey: QKMMESWNJMOPIF-UHFFFAOYSA-N
• SMILES: CN(Cc1cccc(-c2ccccc2)c1)C(=O)Oc1cccc(-c2ccc(C(N)=O)cc2)c1
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.631

英文别名

• 4'-Carbamoyl-3-biphenylyl (3-biphenylylmethyl)methylcarbamate
• Carbamic acid, N-([1,1'-biphenyl]-3-ylmethyl)-N-methyl-, 4'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester