PROSTAGLANDIN A2

Modify Date: 2024-01-02 10:19:27

PROSTAGLANDIN A2 structure	Common Name	PROSTAGLANDIN A2
	CAS Number	13345-50-1	Molecular Weight	334.450
	Density	1.1±0.1 g/cm3	Boiling Point	515.3±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₃₀O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	279.6±26.6 °C

Use of PROSTAGLANDIN A2

Prostaglandin A2 (PGA2), a human endogenous metabolite of PGE2, is an antitumor agent. Prostaglandin A2 induces p53-dependent Apoptosis. Prostaglandin A2 also has antiviral activity[1][2][3].

Name	prostaglandin A2
Synonym	More Synonyms

Description	Prostaglandin A2 (PGA2), a human endogenous metabolite of PGE2, is an antitumor agent. Prostaglandin A2 induces p53-dependent Apoptosis. Prostaglandin A2 also has antiviral activity[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection
Target	Human Endogenous Metabolite
References	[1]. Lee SB, et al. Induction of p53-Dependent Apoptosis by Prostaglandin A2. Biomolecules. 2020 Mar 24;10(3):492. [2]. Gorospe M, et al. Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells. Mol Cell Biol. 1996 Dec;16(12):6654-60. [3]. O'Brien WJ, et al. Assessment of antiviral activity, efficacy, and toxicity of prostaglandin A2 in a rabbit model of herpetic keratitis. Antimicrob Agents Chemother. 1996 Oct;40(10):2327-31.

Density	1.1±0.1 g/cm3
Boiling Point	515.3±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₃₀O₄
Molecular Weight	334.450
Flash Point	279.6±26.6 °C
Exact Mass	334.214417
PSA	74.60000
LogP	3.25
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.555

PROSTAGLANDIN A2 MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK8050000

CHEMICAL NAME :: Prostaglandin A(sup 2)

CAS REGISTRY NUMBER :: 13345-50-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H30-O4

MOLECULAR WEIGHT :: 334.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 93 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,460,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5 mg/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 1,191,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 10 mg/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 1,191,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 10 mg/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 2,295,1972 *** REVIEWS *** TOXICOLOGY REVIEW CSPEAX Cosmetics and Perfumery. (Oak Park, IL) V.88-90, 1973-75. For publisher information, see CTOIDG. Volume(issue)/page/year: 90(12),28,1975

Hazard Codes	F: Flammable;Xi: Irritant;
Risk Phrases	R11
Safety Phrases	S26
RIDADR	UN 1231 3/PG 2

Precursor 9
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DownStream 4
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