MT-3014

Modify Date: 2025-09-21 14:34:35

MT-3014 Structure
MT-3014 structure
Common Name MT-3014
CAS Number 1332727-40-8 Molecular Weight 453.49
Density N/A Boiling Point N/A
Molecular Formula C23H25F2N7O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MT-3014


MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively[1].

 Names

Name MT-3014

 MT-3014 Biological Activity

Description MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively[1].
Related Catalog
Target

human PDE 10A:0.062 nM (IC50)

bovine PDE 10A:0.09 nM (IC50)

References

[1]. Koizumi Y, et al. Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. Bioorg Med Chem. 2019 Jun 19.

 Chemical & Physical Properties

Molecular Formula C23H25F2N7O
Molecular Weight 453.49
InChIKey PUJFXPWIBOJQHB-OAHLLOKOSA-N
SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(N3CCC(F)C3)cc(NCC(C)(C)O)n2n1
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