Tolnaftate-d7

Modify Date: 2022-05-08 10:34:09

Tolnaftate-d7 Structure
Tolnaftate-d7 structure
Common Name Tolnaftate-d7
CAS Number 1329835-64-4 Molecular Weight 314.453
Density 1.2±0.1 g/cm3 Boiling Point 453.4±38.0 °C at 760 mmHg
Molecular Formula C19H10D7NOS Melting Point N/A
MSDS N/A Flash Point 228.0±26.8 °C

 Use of Tolnaftate-d7


Tolnaftate D7 (NP-27 D7) is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent[1][2].

 Names

Name Tolnaftate-d7
Synonym More Synonyms

 Tolnaftate-d7 Biological Activity

Description Tolnaftate D7 (NP-27 D7) is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Ryder, N.S., I. Frank, and M.C. Dupont, Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother, 1986. 29(5): p. 858-60.

[3]. Georgopapadakou, N.H. and A. Bertasso, Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother, 1992. 36(8): p. 1779-81.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 453.4±38.0 °C at 760 mmHg
Molecular Formula C19H10D7NOS
Molecular Weight 314.453
Flash Point 228.0±26.8 °C
Exact Mass 314.147034
LogP 5.15
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.697

 Synonyms

Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-2-naphthalenyl-d7 ester
Tolnaftate-d7
O-(2H7)-2-Naphthyl methyl(3-methylphenyl)carbamothioate