1329835-64-4

1329835-64-4 structure

Name: Tolnaftate-d7
Chemical Name: Tolnaftate-d7
CAS Number: 1329835-64-4
Molecular Formula: C₁₉H₁₀D₇NOS
Molecular Weight: 314.453
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2021-06-12 09:58:23
Modify Date: 2022-05-08 10:34:09
Tolnaftate D7 (NP-27 D7) is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent[1][2].

Name	Tolnaftate-d7
Synonyms	Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-2-naphthalenyl-d7 ester Tolnaftate-d7 O-(2H7)-2-Naphthyl methyl(3-methylphenyl)carbamothioate

Description	Tolnaftate D7 (NP-27 D7) is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Ryder, N.S., I. Frank, and M.C. Dupont, Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother, 1986. 29(5): p. 858-60. [3]. Georgopapadakou, N.H. and A. Bertasso, Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother, 1992. 36(8): p. 1779-81.