Org 12962

Modify Date: 2024-04-03 18:54:45

Org 12962 structure	Common Name	Org 12962
	CAS Number	132834-56-1	Molecular Weight	265.66300
	Density	1.454g/cm3	Boiling Point	286.004ºC at 760 mmHg
	Molecular Formula	C₁₀H₁₁ClF₃N₃	Melting Point	N/A
	MSDS	N/A	Flash Point	126.771ºC

Use of Org 12962

Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2].

Name	1-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine
Synonym	More Synonyms

Description	Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT2C Receptor:7.01 (pEC50) 5-HT2A Receptor:6.38 (pEC50) 5-HT2B Receptor:6.28 (pEC50)
In Vivo	Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) significantly increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%)[1]. Animal Model: Male Wistar rats[2] Dosage: 0.3 mg/kg, 1 mg/kg, 3.2 mg/kg Administration: Intraperitoneal injection; 0.3-3.2 mg/kg Result: Induced a dose-related antipanic-like effect.
References	[1]. Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20. [2]. Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. [3]. Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22.

Density	1.454g/cm3
Boiling Point	286.004ºC at 760 mmHg
Molecular Formula	C₁₀H₁₁ClF₃N₃
Molecular Weight	265.66300
Flash Point	126.771ºC
Exact Mass	265.05900
PSA	28.16000
LogP	2.55720
Vapour Pressure	0.001mmHg at 25°C
Index of Refraction	1.541

HS Code	2933990090

Precursor 2
CAS#:110-85-0 Piperazine CAS#:55304-75-1 2,6-Dichloro-3-...
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

MFCD00892750

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Org 12962
Price: ￥1016.0/250mg ￥2536.0/1g ￥636.0/100mg
Purity: 95.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Org-12962
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-[6-Chloro-5-(trifluoromethyl)-2-pyridinyl]-piperazine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Org 12962

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