210821-63-9

210821-63-9 structure

Name: Org 12962 HCl
Chemical Name: 1-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine,hydrochloride
CAS Number: 210821-63-9
Molecular Formula: C₁₀H₁₂Cl₂F₃N₃
Molecular Weight: 302.12400
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2017-10-15 05:43:36
Modify Date: 2024-01-08 18:42:18
Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model[2].

Name	1-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine,hydrochloride
Synonyms	i02-2815

Description	Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT2C Receptor:7.01 (pEC50) 5-HT2A Receptor:6.38 (pEC50) 5-HT2B Receptor:6.28 (pEC50)
In Vivo	Org 12962 (intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects[3]. Animal Model: Male Wistar rats[3] Dosage: 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg Administration: Intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg Result: Had a dose-related antipanic-like effect in SD-rat.
References	[1]. Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20. [2]. Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. [3]. Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22.

Boiling Point	387.1ºC at 760 mmHg
Molecular Formula	C₁₀H₁₂Cl₂F₃N₃
Molecular Weight	302.12400
Flash Point	187.9ºC
Exact Mass	301.03600
PSA	28.16000
LogP	3.35920
Vapour Pressure	3.37E-06mmHg at 25°C

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

210821-63-9	132834-56-1
62322-24-1	4781-53-7
722456-08-8	104884-91-5
155768-17-5	83507-02-2
135928-30-2	495076-64-7