HNMPA

Modify Date: 2024-01-02 18:24:33

HNMPA structure	Common Name	HNMPA
	CAS Number	132541-52-7	Molecular Weight	238.17600
	Density	1.514g/cm3	Boiling Point	527.2ºC at 760mmHg
	Molecular Formula	C₁₁H₁₁O₄P	Melting Point	N/A
	MSDS	N/A	Flash Point	272.6ºC

Use of HNMPA

HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]

Name	[Hydroxy(2-naphthyl)methyl]phosphonic acid
Synonym	More Synonyms

Description	HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor
In Vitro	HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors[1]. HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application[2].
References	[1]. K Baltensperger, et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7885-9. [2]. Peter Kovacs, et al. In vivo electrophysiological effects of insulin in the rat brain. Neuropeptides. 2009 Aug;43(4):283-93.

Density	1.514g/cm3
Boiling Point	527.2ºC at 760mmHg
Molecular Formula	C₁₁H₁₁O₄P
Molecular Weight	238.17600
Flash Point	272.6ºC
Exact Mass	238.03900
PSA	87.57000
LogP	2.00840