HNMPA
Names
Biological Activity
[Description]:
HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]
[Related Catalog]:
[In Vitro]
HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors[1]. HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application[2].
[References]
Chemical & Physical Properties
[ Density]:
1.514g/cm3
[ Boiling Point ]:
527.2ºC at 760mmHg
[ Molecular Formula ]:
C11H11O4P
[ Molecular Weight ]:
238.17600
[ Flash Point ]:
272.6ºC
[ Exact Mass ]:
238.03900
[ PSA ]:
87.57000
[ LogP ]:
2.00840
Safety Information
[ Hazard Codes ]:
Xi