HNMPA-(AM)3

Names

[ CAS No. ]:
120944-03-8

[ Name ]:
HNMPA-(AM)3

[Synonym ]:
Phosphonic acid, P-[[(acetyloxy)methoxy]-2-naphthalenylmethyl]-, bis[(acetyloxy)methyl] ester
hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester
3-(Acetoxymethoxy)-4-(2-naphthyl)-3-oxido-8-oxo-2,5,7-trioxa-3λ5-phosphanon-1-yl acetate

Biological Activity

[Description]:

HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor

[References]

[1]. Gu SH, et al. PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca²⁺/calmodulin and receptor tyrosine kinase. J Insect Physiol. 2010;56(1):93-101.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
573.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₃O₁₀P

[ Molecular Weight ]:
454.364

[ Flash Point ]:
313.2±50.4 °C

[ Exact Mass ]:
454.102875

[ LogP ]:
4.41

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.543

Related Compounds

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