N-Benzoyl-(2R,3S)-3-phenylisoserine

Modify Date: 2024-01-02 19:26:35

N-Benzoyl-(2R,3S)-3-phenylisoserine Structure
N-Benzoyl-(2R,3S)-3-phenylisoserine structure
Common Name N-Benzoyl-(2R,3S)-3-phenylisoserine
CAS Number 132201-33-3 Molecular Weight 285.29500
Density 1.316g/cm3 Boiling Point 580.7ºC at 760 mmHg
Molecular Formula C16H15NO4 Melting Point 169-172 °C(lit.)
MSDS Chinese USA Flash Point 305ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of N-Benzoyl-(2R,3S)-3-phenylisoserine


N-Benzoyl-(2R,3S)-3-phenylisoserine is a Taxol C-13 Side Chain and crucial for the strong antitumor activity of Taxol[1].

 Names

Name (2R,3S)-N-Benzoyl-3-phenyl Isoserine
Synonym More Synonyms

 N-Benzoyl-(2R,3S)-3-phenylisoserine Biological Activity

Description N-Benzoyl-(2R,3S)-3-phenylisoserine is a Taxol C-13 Side Chain and crucial for the strong antitumor activity of Taxol[1].
Related Catalog
References

[1]. Iwao Ojima, et al. Efficient and Practical Asymmetric Synthesis of the Taxol C-13 Side Chain, N-Benzoyl-(2R,3S)-3-phenylisoserinea,n d Its Analogues via Chiral3-Hydroxy-4-aryl-&lactams through Chiral Ester Enolate-Imine Cyclocondensation.

 Chemical & Physical Properties

Density 1.316g/cm3
Boiling Point 580.7ºC at 760 mmHg
Melting Point 169-172 °C(lit.)
Molecular Formula C16H15NO4
Molecular Weight 285.29500
Flash Point 305ºC
Exact Mass 285.10000
PSA 86.63000
LogP 1.99410
Vapour Pressure 2.51E-14mmHg at 25°C
Index of Refraction 1.625
Storage condition -20℃

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

 Articles8

More Articles
Kingston, D.G.I. et al.

J. Nat. Prod. 53 , 1, (1990)

Mangatal, L. et al.

Tetrahedron 45 , 4177, (1989)

Borman, S.

Chem. Eng. News 69(35) , 11, (1991)

 Synonyms

(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoic acid
MFCD00274633
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