Pyr10
Modify Date: 2024-01-08 14:11:21
Pyr10 structure
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Common Name | Pyr10 | ||
|---|---|---|---|---|
| CAS Number | 1315323-00-2 | Molecular Weight | 449.370 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 470.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C18H13F6N3O2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 238.1±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Pyr10Pyr10is a novel TRPC3-selective inhibitor, IC50 of Ca2+ influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 0.72 uM and 13.08 uM.IC50 value: 0.72 uM (TRPC3-ROCE), 13.08 uM (SOCE) [1]Target: TRPC3in vitro: Pyr10 displays substantial selectivity for TRPC3-mediated responses (18-fold) and the selective block of TRPC3 channels by Pyr10 barely affected mast cell activation.[1] |
| Name | Pyr10 |
|---|---|
| Synonym | More Synonyms |
| Description | Pyr10is a novel TRPC3-selective inhibitor, IC50 of Ca2+ influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 0.72 uM and 13.08 uM.IC50 value: 0.72 uM (TRPC3-ROCE), 13.08 uM (SOCE) [1]Target: TRPC3in vitro: Pyr10 displays substantial selectivity for TRPC3-mediated responses (18-fold) and the selective block of TRPC3 channels by Pyr10 barely affected mast cell activation.[1] |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 470.1±55.0 °C at 760 mmHg |
| Molecular Formula | C18H13F6N3O2S |
| Molecular Weight | 449.370 |
| Flash Point | 238.1±31.5 °C |
| Exact Mass | 449.063263 |
| LogP | 5.16 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.556 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| N-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methylbenzenesulfonamide |
| Benzenesulfonamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl- |