Name | Pyr10 |
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Synonyms |
N-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methylbenzenesulfonamide
Benzenesulfonamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl- |
Description | Pyr10is a novel TRPC3-selective inhibitor, IC50 of Ca2+ influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 0.72 uM and 13.08 uM.IC50 value: 0.72 uM (TRPC3-ROCE), 13.08 uM (SOCE) [1]Target: TRPC3in vitro: Pyr10 displays substantial selectivity for TRPC3-mediated responses (18-fold) and the selective block of TRPC3 channels by Pyr10 barely affected mast cell activation.[1] |
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Related Catalog | |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 470.1±55.0 °C at 760 mmHg |
Molecular Formula | C18H13F6N3O2S |
Molecular Weight | 449.370 |
Flash Point | 238.1±31.5 °C |
Exact Mass | 449.063263 |
LogP | 5.16 |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.556 |
Storage condition | 2-8℃ |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302-H319 |
Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |