Tubulin inhibitor 7

Modify Date: 2025-08-24 22:14:16

Tubulin inhibitor 7 Structure
Tubulin inhibitor 7 structure
Common Name Tubulin inhibitor 7
CAS Number 1309925-41-4 Molecular Weight 358.35
Density N/A Boiling Point N/A
Molecular Formula C21H14N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tubulin inhibitor 7


Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC50 of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC50 of 11 nM[1].

 Names

Name Tubulin inhibitor 7

 Tubulin inhibitor 7 Biological Activity

Description Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC50 of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC50 of 11 nM[1].
Related Catalog
Target

IC50: 0.52 μM (tubulin polymerization)[1]

In Vitro Tubulin inhibitor 7 blocks mitosis through an arrest of cells in the G2/M phase, as illustrated in typical histograms[1]. Tubulin inhibitor 7 shows excellent antiproliferative potencies with IC50s of 40, 24, 16, 6, 29, and 16 nM for NCIH460, SKOV3, BT549, 451LU, SW480, and DLD-1 tumor cell lines, recpectively[1].
References

[1]. Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63.

 Chemical & Physical Properties

Molecular Formula C21H14N2O4
Molecular Weight 358.35

 Safety Information

Hazard Codes Xi
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