MK-8931

Modify Date: 2025-08-27 00:05:15

Use of MK-8931

Verubecestat (MK-8931) is a beta-secretase 1 (BACE1) inhibitor under investigation for the treatment of Alzheimer's Disease.

Name	Verubecestat
Synonym	More Synonyms

Description	Verubecestat (MK-8931) is a beta-secretase 1 (BACE1) inhibitor under investigation for the treatment of Alzheimer's Disease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
References	[1]. Yan R Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs. Transl Neurodegener. 2016 Jul 14;5:13. [2]. Nisha CM et al. Molecular Docking and In Silico ADMET Study Reveals Acylguanidine 7a as a Potential Inhibitor of β-Secretase. Adv Bioinformatics. 2016 Apr 10.

Description

Verubecestat (MK-8931) is a beta-secretase 1 (BACE1) inhibitor under investigation for the treatment of Alzheimer's Disease.

Related Catalog

Signaling Pathways >> Neuronal Signaling >> Beta-secretase

Research Areas >> Neurological Disease

References

Density	1.5±0.1 g/cm3
Molecular Formula	C₁₇H₁₇F₂N₅O₃S
Molecular Weight	409.410
Exact Mass	409.102020
PSA	126.13000
LogP	-0.56
Index of Refraction	1.655
InChIKey	YHYKUSGACIYRML-KRWDZBQOSA-N
SMILES	CN1C(N)=NC(C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS1(=O)=O
Storage condition	-20℃

UNII-J1I0P6WT7T

MK-8931-009

N-{3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoro-2-pyridinecarboxamide

N-{3-[(5R)-3-amino-2,5-diméthyl-1,1-dioxo-1,2,5,6- tétrahydro-1λ6,2,4-thiadiazin-5-yl]-4-fluorophényl}- 5-fluoropyridine-2-carboxamide

(R)-N-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide

Verubecestat

MK8931

2-Pyridinecarboxamide, N-[3-[(5R)-3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-

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Price: $88/10mM*1mLinDMSO

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