1286770-55-5

1286770-55-5 structure

Name: MK-8931
Chemical Name: Verubecestat
CAS Number: 1286770-55-5
Molecular Formula: C₁₇H₁₇F₂N₅O₃S
Molecular Weight: 409.410
Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
Create Date: 2018-02-14 08:00:00
Modify Date: 2024-01-02 18:35:24
Verubecestat (MK-8931) is a beta-secretase 1 (BACE1) inhibitor under investigation for the treatment of Alzheimer's Disease.

Name	Verubecestat
Synonyms	UNII-J1I0P6WT7T MK-8931-009 N-{3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoro-2-pyridinecarboxamide N-{3-[(5R)-3-amino-2,5-diméthyl-1,1-dioxo-1,2,5,6- tétrahydro-1λ6,2,4-thiadiazin-5-yl]-4-fluorophényl}- 5-fluoropyridine-2-carboxamide (R)-N-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide Verubecestat MK8931 2-Pyridinecarboxamide, N-[3-[(5R)-3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-

Description	Verubecestat (MK-8931) is a beta-secretase 1 (BACE1) inhibitor under investigation for the treatment of Alzheimer's Disease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
References	[1]. Yan R Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs. Transl Neurodegener. 2016 Jul 14;5:13. [2]. Nisha CM et al. Molecular Docking and In Silico ADMET Study Reveals Acylguanidine 7a as a Potential Inhibitor of β-Secretase. Adv Bioinformatics. 2016 Apr 10.