JNK-1-IN-1

Modify Date: 2025-08-30 22:22:35

JNK-1-IN-1 Structure
JNK-1-IN-1 structure
Common Name JNK-1-IN-1
CAS Number 1262406-02-9 Molecular Weight 426.53700
Density N/A Boiling Point N/A
Molecular Formula C24H22N6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JNK-1-IN-1


JNK-1-IN-1 is a JNK-1 inhibitor. JNK-1-IN-1 also inhibits MKK7 with an IC50 of 7.8μM. JNK-1-IN-1 bind to MKK7cp and acts as an inhibitor of JNK-1[1].

 Names

Name N-Propyl-N-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,3-benzo thiazol-2-amine

 JNK-1-IN-1 Biological Activity

Description JNK-1-IN-1 is a JNK-1 inhibitor. JNK-1-IN-1 also inhibits MKK7 with an IC50 of 7.8μM. JNK-1-IN-1 bind to MKK7cp and acts as an inhibitor of JNK-1[1].
Related Catalog
Target

JNK1

In Vitro JNK-1-IN-1 (Compound 2) 对 HepG2 人肝癌细胞中的 Jnk1-u、p38α-u、ERK2-u 具有亲和力,Kd 值分别为 11、18、18[1]。 JNK-1-IN-1 抑制 HepG2 人肝癌细胞中的 MKK7cp,IC50 值为 7.8[1]。
References

[1]. Comess KM, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6(3):234-44.  

 Chemical & Physical Properties

Molecular Formula C24H22N6S
Molecular Weight 426.53700
Exact Mass 426.16300
PSA 98.83000
LogP 5.56000
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