600125-11-9
600125-11-9 structure
- Name: TASK-1-IN-1
- Chemical Name: TASK-1-IN-1
- CAS Number: 600125-11-9
- Molecular Formula: C22H20N2O2
- Molecular Weight: 344.41
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2023-01-14 14:17:14
- Modify Date: 2025-11-03 18:39:17
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TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel) inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects[1].
| Name | TASK-1-IN-1 |
|---|
| Description | TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel) inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects[1]. |
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| Related Catalog | |
| Target |
IC50: 148 nM (TASK-1) and 1750 nM (TASK-3)[1] |
| In Vitro | TASK-1-IN-1 (compound F3) blocks cell proliferation and viability in the MCF-7 cancer cell line but not in TASK-1 knockdown MCF-7 cells, indicating that it is acting in TASK-1 channels[1]. Cell Proliferation Assay[1] Cell Line: MCF-7 cells Concentration: 10 μM Incubation Time: 96 hours Result: Showed an antiproliferative activity of ∼45% on the cell line MCF-7. |
| References |
| Molecular Formula | C22H20N2O2 |
|---|---|
| Molecular Weight | 344.41 |