GDC-046

Modify Date: 2024-01-10 12:42:15

GDC-046 structure	Common Name	GDC-046
	CAS Number	1258292-64-6	Molecular Weight	350.199
	Density	1.5±0.1 g/cm3	Boiling Point	518.0±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₃Cl₂N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	267.1±30.1 °C

Use of GDC-046

GDC-046 is a potent, selective, and orally bioavailable TYK2 inhibitor with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively[1].

Name	2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
Synonym	More Synonyms

Description	GDC-046 is a potent, selective, and orally bioavailable TYK2 inhibitor with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	Tyk2:4.8 nM (Ki) JAK1:0.7 nM (Ki) JAK2:0.7 nM (Ki) JAK3:0.4 nM (Ki)
In Vitro	In cell-based assays, GDC-046 demonstrates reasonable potency in blocking the IL-12 pathway (IL-12 pSTAT4 EC50=380 nM) while displaying less activity in the EPO (JAK2) pathway (EPO pSTAT5 EC50=1700 nM) and IL-6 (JAK1) pathway (IL-6 pSTAT3 EC50=2000 nM)[1].
In Vivo	In mice, GDC-046 exhibits relatively high clearance (65 mL/min/kg) when dosed intravenously (i.v. 1 mg/kg) and exhibits modest oral exposure (AUC=2.6 μM·h at p.o. 5 mg/kg)[1].
References	[1]. Jun Liang, et al. Lead Optimization of a 4-aminopyridine Benzamide Scaffold to Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors. J Med Chem. 2013 Jun 13;56(11):4521-36.

Density	1.5±0.1 g/cm3
Boiling Point	518.0±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₃Cl₂N₃O₂
Molecular Weight	350.199
Flash Point	267.1±30.1 °C
Exact Mass	349.038483
PSA	71.09000
LogP	3.12
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.721

2,6-Dichloro-N-{2-[(cyclopropylcarbonyl)amino]-4-pyridinyl}benzamide

Benzamide, 2,6-dichloro-N-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-

GDC046

DC Chemicals Limited
China
Product Name: GDC046
Price: $650.0/100mg $1200.0/250mg $2500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

GDC-046 suppliers

GDC-046 price

GDC-046

Use of GDC-046

Names

GDC-046 Biological Activity

Chemical & Physical Properties

Synonyms