WF-210
Modify Date: 2025-09-01 20:30:48
WF-210 structure
|
Common Name | WF-210 | ||
|---|---|---|---|---|
| CAS Number | 1242279-00-0 | Molecular Weight | 791.855 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C41H38FN7O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of WF-210WF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM, displays more cytotoxic than PAC‐1 to human cancer cells, but less cytotoxic to normal cells; exhibits an enhanced zinc chelating ability (EC50=2.88 uM) compared to PAC‐1, activates procaspase-3 through relief of zinc-mediated inhibition; more potently induces cancer cell death in vitro with mean IC50 of 0.88 uM against 15 cancer cell lines, induces apoptosis in HL-60 and U-937 cells via a caspase-dependent pathway, activates procaspase-3, reduces IAPs, and inhibits tumor growth in breast, liver, and gallbladder xenograft tumor models. |
| Name | WF-210 |
|---|
| Description | WF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM, displays more cytotoxic than PAC‐1 to human cancer cells, but less cytotoxic to normal cells; exhibits an enhanced zinc chelating ability (EC50=2.88 uM) compared to PAC‐1, activates procaspase-3 through relief of zinc-mediated inhibition; more potently induces cancer cell death in vitro with mean IC50 of 0.88 uM against 15 cancer cell lines, induces apoptosis in HL-60 and U-937 cells via a caspase-dependent pathway, activates procaspase-3, reduces IAPs, and inhibits tumor growth in breast, liver, and gallbladder xenograft tumor models. |
|---|---|
| References | References 1. Wang F, et al. Eur J Pharmacol. 2018 Feb 15;821:29-38. 2. Wang F, et al. Mol Oncol. 2014 Dec;8(8):1640-52. View Related Products by Target Caspase |
| Molecular Formula | C41H38FN7O7S |
|---|---|
| Molecular Weight | 791.855 |
| InChIKey | UBTUDBNKVUIOLS-PZUSPJSTSA-N |
| SMILES | O=C(CN1CCN(Cc2nc(-c3ccc(COc4ccc(F)cc4)cc3)no2)CC1)NN=Cc1ccc(OCc2csc(Cc3ccc4c(c3)OCO4)n2)cc1O |