Kobophenol A

Modify Date: 2024-01-12 04:30:26

Kobophenol A structure	Common Name	Kobophenol A
	CAS Number	124027-58-3	Molecular Weight	924.94100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₆H₄₄O₁₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Kobophenol A

Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 µM[1][2].

Name	5-[(2S,3R,4S,5S)-4-[(2S,3S)-3-[(2R,3R)-3-(3,5-dihydroxyphenyl)-6-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuran-4-yl]-6-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuran-4-yl]-2,5-bis(4-hydroxyphenyl)oxolan-3-yl]benzene-1,3-diol
Synonym	More Synonyms

Description	Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 µM[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> TGF-beta/Smad >> PKC
References	[1]. Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12(7):1793-1802. [2]. Xu G, Zhang LP, Chen LF, Hu CQ. Yao Xue Xue Bao. 1994;29(11):818-822.

Description

Related Catalog

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

Signaling Pathways >> TGF-beta/Smad >> PKC

References

[1]. Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12(7):1793-1802.

[2]. Xu G, Zhang LP, Chen LF, Hu CQ. Yao Xue Xue Bao. 1994;29(11):818-822.

Molecular Formula	C₅₆H₄₄O₁₃
Molecular Weight	924.94100
Exact Mass	924.27800
PSA	229.99000
LogP	10.65400

Hazard Codes	Xn

C6H4NO2.K

K-nicotinate

3-Pyridinecarboxylic acid,potassium salt

Nicotinic acid,potassium salt

kobophenol A

Potassium nicotinate

(2S,2'R,3S,3'R)-3'-(3,5-dihydroxyphenyl)-4-[(2S,3S,4R,5S)-4-(3,5-dihydroxyphenyl)tetrahydro-2,5-bis(4-hydroxyphenyl)-3-furanyl]-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)-[3,4'-bibenzofuran]-6,6'-diol

Niacin Potassium Salt

Potassium 3-pyridinecarboxylate

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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Kobophenol A
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Kobophenol A

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