Kobophenol A

Names

[ Name ]:
Kobophenol A

[Synonym ]:
C6H4NO2.K
K-nicotinate
3-Pyridinecarboxylic acid,potassium salt
Nicotinic acid,potassium salt
kobophenol A
Potassium nicotinate
(2S,2'R,3S,3'R)-3'-(3,5-dihydroxyphenyl)-4-[(2S,3S,4R,5S)-4-(3,5-dihydroxyphenyl)tetrahydro-2,5-bis(4-hydroxyphenyl)-3-furanyl]-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)-[3,4'-bibenzofuran]-6,6'-diol
Niacin Potassium Salt
Potassium 3-pyridinecarboxylate

Biological Activity

[Description]:

Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 µM[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

Signaling Pathways >> TGF-beta/Smad >> PKC

[References]

[1]. Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12(7):1793-1802.

[2]. Xu G, Zhang LP, Chen LF, Hu CQ. Yao Xue Xue Bao. 1994;29(11):818-822.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₆H₄₄O₁₃

[ Molecular Weight ]:
924.94100

[ Exact Mass ]:
924.27800

[ PSA ]:
229.99000

[ LogP ]:
10.65400

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds

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