Thymolphthalein monophosphate disodium hydrate

Modify Date: 2024-01-11 22:04:17

Thymolphthalein monophosphate disodium hydrate Structure
Thymolphthalein monophosphate disodium hydrate structure
Common Name Thymolphthalein monophosphate disodium hydrate
CAS Number 123359-43-3 Molecular Weight 572.49400
Density N/A Boiling Point 683.3ºC at 760mmHg
Molecular Formula C28H31Na2O8P Melting Point N/A
MSDS N/A Flash Point 367.1ºC

 Use of Thymolphthalein monophosphate disodium hydrate


Thymolphthalein monophosphate disodium hydrate is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. Thymolphthalein is released during the reaction, increases the pH of the medium for easy detection, produces color and stops hydrolysis. Thymolphthalein monophosphate disodium hydrate can be used for the specific detection of prostatic phosphatase in serum[1][2].

 Names

Name Thymolphthalein monophosphoric acid disodium salt trihydrate
Synonym More Synonyms

  Biological Activity

Description Thymolphthalein monophosphate disodium hydrate is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. Thymolphthalein is released during the reaction, increases the pH of the medium for easy detection, produces color and stops hydrolysis. Thymolphthalein monophosphate disodium hydrate can be used for the specific detection of prostatic phosphatase in serum[1][2].
Related Catalog
References

[1]. Roy AV, et al. Sodium thymolphthalein monophosphate: a new acid phosphatase substrate with greater specificity for the prostatic enzyme in serum. Clin Chem. 1971 Nov;17(11):1093-102

[2]. Morin LG. Ammonium thymolphthalein monophosphate as a new substrate for alkaline and acid phosphatase determinations in serum. Clin Chem. 1973 Oct;19(10):1135-8.

 Chemical & Physical Properties

Boiling Point 683.3ºC at 760mmHg
Molecular Formula C28H31Na2O8P
Molecular Weight 572.49400
Flash Point 367.1ºC
Exact Mass 572.15500
PSA 137.99000
LogP 7.00170
Vapour Pressure 1.31E-19mmHg at 25°C

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: Thymolphthalein monophosphate disodium salt hydrate
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:Thymolphthalein monophosphate disodium salt hydrate
CAS number:123359-43-3

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C28H29O7P.2Na.H2O
Molecular weight:572.5

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Safety Phrases S22-S24/25

 Synonyms

thymolphthalein monophosphate disodium salt hydrate
thymolphthalein monophosphate disodium salt n-hydrate
thymolphthalein monophosphoric acid disodium salt xh2o
thymolphthalein monophosphoric acid,dis odium salt hydrate