(+)-KCC2 blocker 1

Modify Date: 2025-09-25 09:27:10

(+)-KCC2 blocker 1 structure	Common Name	(+)-KCC2 blocker 1
	CAS Number	1228439-71-1	Molecular Weight	415.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₅NO₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (+)-KCC2 blocker 1

(+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1[1].

Name	(+)-KCC2 blocker 1

Description	(+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 0.4 μM (KCC2)[1]
In Vitro	(+)-KCC2 blocker 1 ((+)-13), a enantiomers of KCC2 blocker 1, has a 100-fold difference in potency compare with enantiomer (-)-KCC2 blocker 1 ((−)-13))[1].
References	[1]. Pégurier C, et al. Benzyl prolinate derivatives as novel selective KCC2 blockers. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2542-5.

Molecular Formula	C₂₂H₂₅NO₅S
Molecular Weight	415.50

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