1228439-71-1

1228439-71-1 structure

1228439-71-1 structure

Name: (+)-KCC2 blocker 1
Chemical Name: (+)-KCC2 blocker 1
CAS Number: 1228439-71-1
Molecular Formula: C₂₂H₂₅NO₅S
Molecular Weight: 415.50
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2020-06-01 22:49:27
Modify Date: 2024-01-09 16:40:28
(+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1[1].

Name	(+)-KCC2 blocker 1

Description	(+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 0.4 μM (KCC2)[1]
In Vitro	(+)-KCC2 blocker 1 ((+)-13), a enantiomers of KCC2 blocker 1, has a 100-fold difference in potency compare with enantiomer (-)-KCC2 blocker 1 ((−)-13))[1].
References	[1]. Pégurier C, et al. Benzyl prolinate derivatives as novel selective KCC2 blockers. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2542-5.

Molecular Formula	C₂₂H₂₅NO₅S
Molecular Weight	415.50