(+)-KCC2 blocker 1

Names

[ Name ]:
(+)-KCC2 blocker 1

Biological Activity

[Description]:

(+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 0.4 μM (KCC2)[1]

[In Vitro]

(+)-KCC2 blocker 1 ((+)-13), a enantiomers of KCC2 blocker 1, has a 100-fold difference in potency compare with enantiomer (-)-KCC2 blocker 1 ((−)-13))[1].

[References]

[1]. Pégurier C, et al. Benzyl prolinate derivatives as novel selective KCC2 blockers. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2542-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₅NO₅S

[ Molecular Weight ]:
415.50

(+)-KCC2 blocker 1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds