LCL521 dihydrochloride
Modify Date: 2025-08-25 16:35:23
LCL521 dihydrochloride structure
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Common Name | LCL521 dihydrochloride | ||
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| CAS Number | 1226759-47-2 | Molecular Weight | 665.69 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H54Cl2N4O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LCL521 dihydrochlorideLCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase). |
| Name | LCL521 dihydrochloride |
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| Description | LCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase). |
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| Related Catalog | |
| Target |
ACDase, ASMase[1] |
| In Vitro | Acid ceramidase (ACDase) is being recognized as a therapeutic target for cancer. B13 represents a moderate inhibitor of ACDase. LCL521 applied at a lower concentration, 1 µM, shows an effect similar to 10µM treatment, suggesting a high efficiency on this enzyme inhibition. LCL521 causes a time-dependent decrease of the α-ACDase form. 1 µM LCL521 acts as a potent inhibitor of cellular ACDase activity, whereas 10 µM LCL521 has an additional, decreased affect on the α-form of this enzyme. Moreover, LCL521 acts as inhibitor of the lysosomal ACDase and ASMase[1]. |
| Cell Assay | HeLa cells overexpressing ASAH2, ACER2, or empty vector are grown to a 60% confluence before they are treated with Tetracycline (5 ng/mL) overnight. Next day, the cells are then treated with B13 (10 µM), LCL521 (1 or 10 µM), or Ethanol (the vehicle control for both B13 and LCL521) for 1 h before they are harvested[1]. |
| References |
| Molecular Formula | C31H54Cl2N4O7 |
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| Molecular Weight | 665.69 |
| Storage condition | 2-8℃ |