1226851-11-1

1226851-11-1 structure

Name: LCL521
Chemical Name: LCL521
CAS Number: 1226851-11-1
Molecular Formula: C₃₁H₅₂N₄O₇
Molecular Weight: 592.77
Catalog: Research Areas Cancer
Create Date: 2019-03-31 10:27:34
Modify Date: 2025-09-10 20:21:34
LCL521 is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).

Name	LCL521

Description	LCL521 is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	ACDase, ASMase[1]
In Vitro	LCL521 (1 µM) acts as a potent inhibitor of cellular ACDase activity, whereas 10 µM LCL521 has an additional, decreased affect on the α-form of this enzyme. LCL521 (10 µM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells[1].
References	[1]. Bai A, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44.