mTOR inhibitor 10
Modify Date: 2024-01-19 10:57:03
mTOR inhibitor 10 structure
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Common Name | mTOR inhibitor 10 | ||
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| CAS Number | 1222999-54-3 | Molecular Weight | 683.720 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 862.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C41H32F3N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 475.6±34.3 °C | |
Use of mTOR inhibitor 10A novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM; displays >50-fold selectivity over PIKKs (hVSP34, PI3Ks, PI4K, etc.); exhibits significant inhibitory activity against the downstream targets of mTOR, S6K, and Akt, and blocks 80-90% phosphorylation of S6K (T389) and pAkt (S473) in liver and lung tissues, along with significantly improved mouse liver microsome stability and a longer in vivo half-life. |
| Name | N-(1-Methyl-4-piperidinyl)-4'-[2-oxo-9-(3-quinolinyl)benzo[h][1,6]naphthyridin-1(2H)-yl]-2'-(trifluoromethyl)-4-biphenylcarboxamide |
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| Synonym | More Synonyms |
| Description | A novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM; displays >50-fold selectivity over PIKKs (hVSP34, PI3Ks, PI4K, etc.); exhibits significant inhibitory activity against the downstream targets of mTOR, S6K, and Akt, and blocks 80-90% phosphorylation of S6K (T389) and pAkt (S473) in liver and lung tissues, along with significantly improved mouse liver microsome stability and a longer in vivo half-life. |
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| References | References 1. Liu Q, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4036-40. View Related Products by Target mTOR |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 862.8±65.0 °C at 760 mmHg |
| Molecular Formula | C41H32F3N5O2 |
| Molecular Weight | 683.720 |
| Flash Point | 475.6±34.3 °C |
| Exact Mass | 683.250793 |
| LogP | 6.10 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.723 |
| N-(1-Methyl-4-piperidinyl)-4'-[2-oxo-9-(3-quinolinyl)benzo[h][1,6]naphthyridin-1(2H)-yl]-2'-(trifluoromethyl)-4-biphenylcarboxamide |
| [1,1'-Biphenyl]-4-carboxamide, N-(1-methyl-4-piperidinyl)-4'-[2-oxo-9-(3-quinolinyl)benzo[h][1,6]naphthyridin-1(2H)-yl]-2'-(trifluoromethyl)- |
| MFCD27992058 |