PS210
Modify Date: 2024-01-08 18:30:59
PS210 structure
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Common Name | PS210 | ||
|---|---|---|---|---|
| CAS Number | 1221962-86-2 | Molecular Weight | 380.319 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H15F3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PS210PS 210 is a potent, specific activator of PDK1 that target the PIF-binding pocket of PDK1, does not alter the activity of any of the 121 kinases (S6K, PKB/Akt or GSK3). |
| Name | PS 210 |
|---|
| Description | PS 210 is a potent, specific activator of PDK1 that target the PIF-binding pocket of PDK1, does not alter the activity of any of the 121 kinases (S6K, PKB/Akt or GSK3). |
|---|---|
| Related Catalog | |
| Target |
Kd: 3 μM (PDK1)[2] |
| In Vitro | When PS210 induces a stabilization of PDK1 to the temperature gradien, PS210 stabilized the residue Arg131, located opposite to the helix a-B at the other extreme of the helix a-C. Thus, the residues forming part of the phosphate-binding site appear to be a fixed point that allows for the relative movement of the helices in the process of PDK1 activation[1]. |
| References |
| Molecular Formula | C19H15F3O5 |
|---|---|
| Molecular Weight | 380.319 |
| InChIKey | MLJPLHGJBUWCBA-UHFFFAOYSA-N |
| SMILES | O=C(CC(c1ccccc1)C(C(=O)O)C(=O)O)c1ccc(C(F)(F)F)cc1 |
| Storage condition | -20°C |