1410101-89-1

1410101-89-1 structure

Name: (R)-PS210
Chemical Name: (R)-PS210
CAS Number: 1410101-89-1
Molecular Formula: C₁₉H₁₅F₃O₅
Molecular Weight: 380.31
Catalog: Signaling Pathways PI3K/Akt/mTOR PDK-1
Create Date: 2020-04-11 20:21:00
Modify Date: 2024-01-15 18:15:11
(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment[1].

Name	(R)-PS210

Description	(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> PDK-1 Research Areas >> Cancer
Target	AC50: 1.8 μM (PDK1)[1]
In Vitro	(R)-PS210 displays an AC50 value of 1.8 μM towards PDK1 in a Cell-Free Kinase Activity Assay. And the maximum activation of PDK1 compared to DMSO control of (R)-PS210 is 5.5 fold[1].
References	[1]. Wilhelm A, et al. 2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.J Med Chem. 2012 Nov 26;55(22):9817-30.

Molecular Formula	C₁₉H₁₅F₃O₅
Molecular Weight	380.31