PF-04979064

Modify Date: 2024-01-16 17:45:52

Use of PF-04979064

PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.

Name	1-(1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c][1,5]naphthyridin-2-one
Synonym	More Synonyms

Description	PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.
Related Catalog	Research Areas >> Cancer
Target	PI3Kα:0.13 nM (Ki) PI3Kγ:0.111 nM (Ki) PI3Kδ:0.122 nM (Ki) mTOR:1.42 nM (Ki)
In Vitro	PF-04979064 is tested against human class I PI3K isoforms PI3Kα, PI3Kγ, and PI3Kδ, with PI3Kα Ki of 0.13 nM, PI3Kγ Ki of 0.111 nM, and PI3Kδ Ki of 0.122 nM[1].
In Vivo	PF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T1/2=1.85 h, and F%=61%[1].
References	[1]. Cheng H et al. Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett, 2012 Nov 7, 4(1):91-7.

pf-04979064

pf04979064 /pf-04979064

1-{1-[(2S)-2-Hydroxypropanoyl]-4-piperidinyl}-3-methyl-8-(6-methyl-3-pyridinyl)-1,3-dihydro-2H-imidazo[4,5-c][1,5]naphthyridin-2-one

2H-Imidazo[4,5-c][1,5]naphthyridin-2-one, 1,3-dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-

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Price: $106/10mM*1mLinDMSO

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