Rizatriptan-d6 (benzoate salt)

Modify Date: 2025-08-22 16:56:16

Rizatriptan-d6 (benzoate salt) Structure
Rizatriptan-d6 (benzoate salt) structure
Common Name Rizatriptan-d6 (benzoate salt)
CAS Number 1216984-85-8 Molecular Weight 397.50300
Density N/A Boiling Point N/A
Molecular Formula C22H19D6N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Rizatriptan-d6 (benzoate salt)


Rizatriptan-d6 benzoate (MK 462-d6) is the deuterium labeled Rizatriptan benzoate. Rizatriptan benzoate is a 5-HT1 agonist triptan drug for the treatment of migraine headaches[1][2].

 Names

Name benzoic acid,2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-N,N-bis(trideuteriomethyl)ethanamine
Synonym More Synonyms

 Rizatriptan-d6 (benzoate salt) Biological Activity

Description Rizatriptan-d6 benzoate (MK 462-d6) is the deuterium labeled Rizatriptan benzoate. Rizatriptan benzoate is a 5-HT1 agonist triptan drug for the treatment of migraine headaches[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Sciberras DG, et al. Initial human experience with MK-462 (rizatriptan): a novel 5-HT1D agonist. Br J Clin Pharmacol. 1997 Jan;43(1):49-54.

 Chemical & Physical Properties

Molecular Formula C22H19D6N5O2
Molecular Weight 397.50300
Exact Mass 397.23800
PSA 87.04000
LogP 3.29660

 Synonyms

N,N-(Dimethyl-d6)-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine Benzoate
Maxalt-d6
[2H6]-Rizatriptan benzoate
MK-0462-d6
Rizatriptan-d6 Benzoate
MK-462-d6
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