Rizatriptan-d6 (benzoate salt)

Names

[ Name ]:
Rizatriptan-d6 (benzoate salt)

[Synonym ]:
N,N-(Dimethyl-d6)-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine Benzoate
Maxalt-d6
[2H6]-Rizatriptan benzoate
MK-0462-d6
Rizatriptan-d6 Benzoate
MK-462-d6

Biological Activity

[Description]:

Rizatriptan-d6 benzoate (MK 462-d6) is the deuterium labeled Rizatriptan benzoate. Rizatriptan benzoate is a 5-HT1 agonist triptan drug for the treatment of migraine headaches[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Sciberras DG, et al. Initial human experience with MK-462 (rizatriptan): a novel 5-HT1D agonist. Br J Clin Pharmacol. 1997 Jan;43(1):49-54.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₉D₆N₅O₂

[ Molecular Weight ]:
397.50300

[ Exact Mass ]:
397.23800

[ PSA ]:
87.04000

[ LogP ]:
3.29660

Related Compounds

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