Mirtazapine D3

Modify Date: 2024-01-02 12:48:42

Mirtazapine D3 structure	Common Name	Mirtazapine D3
	CAS Number	1216678-68-0	Molecular Weight	268.37100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₆D₃N₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Mirtazapine D3

Mirtazapine D3 (Org3770 D3; 6-Azamianserin D3) is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].

Name	Mirtazapine-d3

Description	Mirtazapine D3 (Org3770 D3; 6-Azamianserin D3) is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT2 Receptor 5-HT3 Receptor
In Vivo	Mirtazapine (intraperitoneal injection; 10–50 mg/Kg; 14 days) treatment normalizes heart rate, breath rate, anxiety levels and eliminates the hopping behavior observed in MeCP2-null mice, leading to improved phenotypic score[2]. Animal Model: MeCP2 null mice[2] Dosage: 10-50 mg/Kg Administration: Intraperitoneal injection; 10-50 mg/Kg; 14 days Result: Restored the thickness of MeCP2-null mice somatosensory cortex, especially of layers II-III and VI.
References	[1]. Anttila, S.A. and E.V. Leinonen, A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev, 2001. 7(3): p. 249-64. [2]. Kooyman AR, et al. Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells.Neuropharmacology. 1994 Mar-Apr;33(3-4):501-7.

Molecular Formula	C₁₇H₁₆D₃N₃
Molecular Weight	268.37100
Exact Mass	268.17700
PSA	19.37000
LogP	2.48180

Mirtazapine D3

Use of Mirtazapine D3

Names

Mirtazapine D3 Biological Activity

Chemical & Physical Properties