Biotin-PFP ester
Modify Date: 2025-08-25 23:44:04
Biotin-PFP ester structure
|
Common Name | Biotin-PFP ester | ||
|---|---|---|---|---|
| CAS Number | 120550-35-8 | Molecular Weight | 410.359 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 555.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H15F5N2O3S | Melting Point | 190.0 to 194.0 °C | |
| MSDS | N/A | Flash Point | 289.6±30.1 °C | |
Use of Biotin-PFP esterBiotin-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | (2,3,4,5,6-pentafluorophenyl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate |
|---|---|
| Synonym | More Synonyms |
| Description | Biotin-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 555.3±50.0 °C at 760 mmHg |
| Melting Point | 190.0 to 194.0 °C |
| Molecular Formula | C16H15F5N2O3S |
| Molecular Weight | 410.359 |
| Flash Point | 289.6±30.1 °C |
| Exact Mass | 410.072357 |
| PSA | 92.73000 |
| LogP | 2.85 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.513 |
| InChIKey | DKTMDBQDSYQUEV-LEJLMFORSA-N |
| SMILES | O=C1NC2CSC(CCCCC(=O)Oc3c(F)c(F)c(F)c(F)c3F)C2N1 |
| Storage condition | 2-8°C |
|
~98%
Biotin-PFP ester CAS#:120550-35-8 |
| Literature: Korshun, Vladimir A.; Pestov, Nikolai B.; Nozhevnikova, Elena V.; Prokhorenko, Igor A.; Gontarev, Sergei V.; Berlin, Yuri A. Synthetic Communications, 1996 , vol. 26, # 13 p. 2531 - 2547 |
|
~95%
Biotin-PFP ester CAS#:120550-35-8 |
| Literature: Chambers, Jennifer M.; Lindqvist, Lisa M.; Webb, Andrew; Huang, David C. S.; Savage, G. Paul; Rizzacasa, Mark A. Organic Letters, 2013 , vol. 15, # 6 p. 1406 - 1409 |
|
~80%
Biotin-PFP ester CAS#:120550-35-8 |
| Literature: Stewart, Scott G.; Braun, Carlos J.; Polomska, Marta E.; Karimi, Mahdad; Abraham, Lawrence J.; Stubbs, Keith A. Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4059 - 4062 |
|
~96%
Biotin-PFP ester CAS#:120550-35-8 |
| Literature: Rabinkov, A. G.; Pozdnev, V. F.; Amontov, S. V.; Kopelevich, V. M.; Gunar, V. I. Chemistry of Natural Compounds, 1989 , vol. 25, p. 350 - 353 Khimiya Prirodnykh Soedinenii, 1989 , # 3 p. 404 - 408 |
CAS#:359860-27-8
CAS#:72040-64-3| biotin-pentafluoro-phenyl ester |
| Pentafluorophenyl 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate |
| D-biotin pentafluorophenyl ester |
| 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 2,3,4,5,6-pentafluorophenyl ester, (3aS,4S,6aR)- |
| (+)-Biotin-PFP-ester |
| biotinylpentafluorophenyl ester |
| Perfluorophenyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate |
| PFP-Biotin |
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- Shanghai Nianxing Industrial Co., Ltd
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- China
- Product Name: Biotin-PFP ester
- Price: ￥Inquiry/100mg ￥Inquiry/1g ￥Inquiry/250mg ￥Inquiry/5g
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- Delivery: Inquiry
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