sulfurein
Modify Date: 2024-01-05 10:44:24
sulfurein structure
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Common Name | sulfurein | ||
|---|---|---|---|---|
| CAS Number | 120-05-8 | Molecular Weight | 270.237 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 585.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H10O5 | Melting Point | 295ºC | |
| MSDS | N/A | Flash Point | 228.8±23.6 °C | |
Use of sulfureinSulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis[1]. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM[2]. |
| Name | sulfuretin |
|---|---|
| Synonym | More Synonyms |
| Description | Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis[1]. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM[2]. |
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| Related Catalog | |
| In Vitro | Sulfuretin is one of the main flavonoids produced by Rhus verniciflua. Sulfuretin efficiently inhibits the infiltration of inflammatory cells and attenuates allergic airway inflammation. |
| In Vivo | Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation[1]. Animal Model: Pathogen-free male BALB/c mice (7-8 weeks old)[1] Dosage: 40 μg/kg Administration: A single intraperitoneal injection was administered 2 h after the last OVA challenge Result: Suppressed OVA-induced chemotaxis and airway inflammation. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 585.0±50.0 °C at 760 mmHg |
| Melting Point | 295ºC |
| Molecular Formula | C15H10O5 |
| Molecular Weight | 270.237 |
| Flash Point | 228.8±23.6 °C |
| Exact Mass | 270.052826 |
| PSA | 86.99000 |
| LogP | 1.98 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.793 |
| Hazard Codes | Xi |
|---|
| Sulfuretin |
| (Z)-2-((3,4-Dihydroxyphenyl)methylene)-6-hydroxy-2H-benzofuran-3-one |
| 3(2H)-Benzofuranone, 2-[(3,4-dihydroxyphenyl)methylene]-6-hydroxy-, (2Z)- |
| (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one |
| 2-(3,4-Dihydroxybenzylidene)-6-hydroxy-3(2H)-benzofuranone |
| sulfurein |
| 7,3',4'-trihydroxyaurone |
| Sulphuretin |
| MFCD00017304 |
| 3',4',6-Trihydroxybenzalcoumaranone |
| 3',4',6-trihydroxyaurone |
| (2Z)-2-(3,4-Dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one |
| 2-[(3,4-Dihydroxyphenyl)methylene]-6-hydroxy-3(2H)-benzofuranone |