120-05-8

120-05-8 structure

Name: sulfurein
Chemical Name: sulfuretin
CAS Number: 120-05-8
Molecular Formula: C₁₅H₁₀O₅
Molecular Weight: 270.237
Catalog: Natural product Chalcone
Create Date: 2019-01-01 17:43:17
Modify Date: 2024-01-05 10:44:24
Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis[1]. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM[2].

Name	sulfuretin
Synonyms	Sulfuretin (Z)-2-((3,4-Dihydroxyphenyl)methylene)-6-hydroxy-2H-benzofuran-3-one 3(2H)-Benzofuranone, 2-[(3,4-dihydroxyphenyl)methylene]-6-hydroxy-, (2Z)- (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one 2-(3,4-Dihydroxybenzylidene)-6-hydroxy-3(2H)-benzofuranone sulfurein 7,3',4'-trihydroxyaurone Sulphuretin MFCD00017304 3',4',6-Trihydroxybenzalcoumaranone 3',4',6-trihydroxyaurone (2Z)-2-(3,4-Dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one 2-[(3,4-Dihydroxyphenyl)methylene]-6-hydroxy-3(2H)-benzofuranone

Description	Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis[1]. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM[2].
Related Catalog	Research Areas >> Inflammation/Immunology
In Vitro	Sulfuretin is one of the main flavonoids produced by Rhus verniciflua. Sulfuretin efficiently inhibits the infiltration of inflammatory cells and attenuates allergic airway inflammation.
In Vivo	Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation[1]. Animal Model: Pathogen-free male BALB/c mice (7-8 weeks old)[1] Dosage: 40 μg/kg Administration: A single intraperitoneal injection was administered 2 h after the last OVA challenge Result: Suppressed OVA-induced chemotaxis and airway inflammation.
References	[1]. Mi-Young Song, et al. Sulfuretin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2010 Sep 10;400(1):83-8. [2]. Chen, H., et al. Isolation of sulfuretin and butin from Rhus verniciflua Stokes using medium-pressure liquid chromatography and their tyrosinase inhibitory effects. BioRes. 11(1), 759-771.

Hazard Codes	Xi