(5Z)-2-amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one

Modify Date: 2024-04-09 10:48:08

(5Z)-2-amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one structure	Common Name	(5Z)-2-amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one
	CAS Number	1198098-03-1	Molecular Weight	264.300
	Density	1.4±0.1 g/cm3	Boiling Point	454.8±55.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₂N₂O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	228.9±31.5 °C

Use of (5Z)-2-amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one

GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease[1].

Name	5-(3,4-Dimethoxy-benzylidene)-2-imino-thiazolidin-4-one
Synonym	More Synonyms

Description	GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3β:80.5 nM (IC50)
References	[1]. Arfeen M, et al. Design, synthesis and biological evaluation of 5-benzylidene-2-iminothiazolidin-4-ones as selective GSK-3β inhibitors. Eur J Med Chem. 2016 Oct 4;121:727-736.

Density	1.4±0.1 g/cm3
Boiling Point	454.8±55.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₂N₂O₃S
Molecular Weight	264.300
Flash Point	228.9±31.5 °C
Exact Mass	264.056854
LogP	1.73
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.630
Storage condition	-20°C

4(5H)-Thiazolone, 2-amino-5-[(3,4-dimethoxyphenyl)methylene]-, (5Z)-

5-(3,4-Dimethoxy-benzylidene)-2-imino-thiazolidin-4-one

(5Z)-2-Amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one

(5Z)-2-amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one

Use of (5Z)-2-amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one

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